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Possible is a collaboration that develops and tests innovations to improve health in Nepal by directly responding to local concerns, while drawing from and contributing to the broader disciplines of global health research, practice, and policy. Our partnership is between an independent Nepal-based nongovernmental organization and a US-based non-profit. Possible envisions a world where everyone, everywhere has access to high-quality healthcare rooted in evidence, inclusion, and equity. As such, we engage in rigorous and collaborative research and innovation to address evidence, implementation, and policy gaps in the equity, quality, and accessibility of healthcare. Our research endeavors and partnerships aim to address challenges in context and from stated or established needs. Our first commitment is to develop and deploy interventions that improve health (rather than prioritize academic outputs that may be novel and methodologically sound but do not directly improve healthcare). We partner with community based organizations, public and private sector academic institutions and research organizations to leverage research and evidence to inform and implement innovative solutions to healthcare challenges in Nepal. For the last 16 years, we have been a leader in healthcare innovation in Nepal, conducting implementation research with partnerships spanning several international institutions such as Harvard Medical School, University of California San Francisco, Mt. Sinai School of Medicine, and University of Washington.